Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function

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Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia To the Editor: In the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclero-

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Impaired kidney allograft function following ezetimibe therapy.

Although ezetimibe therapy has been shown to be effective in lowering serum cholesterol level, it has not been reported to affect serum cyclosporine level in transplant recipients. Here, we describe a kidney transplant recipient who experienced acute kidney allograft dysfunction after ezetimibe prescription. Our patient showed an increase in serum creatinine level as well as a decrease in serum...

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Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.

BACKGROUND Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitali...

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High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy.

Statins are the frontline in cholesterol reduction therapies; however, their use in combination with agents that possess complimentary mechanisms of action may achieve further reductions in low-density lipoprotein cholesterol. Thirty-nine patients were treated with either 80 mg simvastatin (n=20) or 10 mg simvastatin plus 10 mg ezetimibe (n=19) for 6 weeks. Dosing was designed to produce compar...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2017

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2016090957